Course Objective
Class Syllabus
Requirement
Exams
Class Policy
Research Paper
Bio 211A I Bio 340 I Bio 464 I Bio 468/568  
Bio 490 I

C.         LECTURE TIMES AND VENUE:

Lectures will be held in PH1-219 Tuesdays and Thursdays, 12.30-1.45 p.m. You are responsible for all announcements, assignments, handouts, etc. even if you are late or absent from class.

Recommended Text for Analytical Chemistry Portion of the Class:

Quantitative Chemical Analysis.  5th Edition. Harris, D.C.  W.H. Freeman and Company, New York.  ISBN # 0-7167-2881-8.  QD101.2.H37
Exploring Chemical Analysis.  2nd Edition.  Harris, D.C.  W.H. Freeman and Company, New York.  ISBN # 0-7167-3042-1.  QD75.2.H368
 

LECTURE OUTLINE:  A general lecture outline is given below.  Depending upon the depth and breadth of the subject matter, various topics may cover more than an individual lecture period.  Consequently, no attempt has been made to allocate proposed dates.
 

Lecture Topic
1 Outline of Course Syllabus & Introduction to Aquatic Toxicology. 
2 Major Classes of Pollutants (Inorganics, Organics, Radiation) 
3 Routes by Which Pollutants Enter the Aquatic Ecosystems. A case study of the S. California Bight
4 Direct Chemical methods for the identification, quantification and speciation of  inorganic  pollutants 
5 Direct Chemical methods for the identification, quantification and speciation of  organic  pollutants
6 In Situ biomonitoring systems for water quality assessment
7 Determination of Toxicity: Toxicity Testing.  Trials and Tribulations
8 Toxicity Assessment: End points in Toxicity (Acute versus Chronic; Lethal vs physiological)
9 Behavioral responses to toxicants 
10 Physiological responses to toxicants
11 Biochemical responses to toxicants
12 Cellular and Molecular responses to toxicants
13 Biomarkers of Xenobiotic Stress (organismal, cell/tissue, subcellular)
14 Biomarkers of Xenobiotic Stress (Alarm parameters, Toxicity stress/strain parameters/ Finger print parameter)
15 Molecular Mechanisms of interaction of Inorganics (Metallothioneins)
16 Molecular Mechanisms of interaction of Organics (Cytochrome P-450)
17 Recombinant reporter assays for Toxicological Assessment
18 Case Studies in Toxicology (Cytochrome P-450 induction and Endocrine Disruption by TBT).  5/13/99
19 Microsoft Power point Workshop
20 STUDENT PRESENTATIONS
21 STUDENT PRESENTATIONS
22 STUDENT PRESENTATIONS
23 STUDENT PRESENTATIONS
24  STUDENT PRESENTATIONS
25 FINAL EXAM: Tuesday May 18th, PH1-218 12.30-2.30